Vectric / Partworks
With your Autocad background you should pick things up fairly quickly.
The best thing to do is visit someone and watch them design a few things, you will pick up on a lot of Vectric / Partworks items quickly and then you tend to learn things one or two at a time. Tuition might involve beer, pizza or donuts...
You can design more complex things in Autocad and save it to a 2000 dxf which is a file Vectric / Partworks can open. From there you assign bits and toolpath parameters which takes a while to learn.
I learned today that Keyhole bits break fairly easily...
The decimal point seems to be the most important on the z axis... x & y not so much....
ShopBot... Where even the scraps and things you mess up and throw away are cool....