0,0 location
Sometimes it is simpler to place the material and linework in the design file so it is centered on the point 0,0 ( the material being equal in all four quadrants )
From there, have the home position set to 0,0
From there, locate the bit over the center of where you want to cut and call that point 0,0 / Run the cut files.
Can't hardly miss by too far with this setup.
The decimal point seems to be the most important on the z axis... x & y not so much....
ShopBot... Where even the scraps and things you mess up and throw away are cool....