If you're on the fence about buying a festool domino machine, I'm here to tell you it is a great companion to the shopbot.
Several months ago, I drafted a 10mm domino vector, and have utilized it quite regularly for joinery. When applied to plywood, it saves tedius alignment issues. For joining plywood perpendicularly, you may simply use the domino machine to punch the holes in ends of pieces that but up to the pieces you cut flat on you shopbot. If you've got an accurate drawing, your alignment marks for the end holes can be easily retrieved. Just be sure to do a test cut on scrap to determine exact "height" setting of domino's fence for proper alignment and that you've dialed your alignment marks in on your domino machine for accurate placement over pencil marks for your plunge cuts. (the machines are not perfect from factory)
What's really got me jazzed is I just used them to align bentwood forms I cut from particle board on my PRSalpha. Had to stack 3 flat layers of curved forms - domino holes cut identically in all 3 peices = lift off machine, tap dominos in place = perfect alignment.
Spending less time building forms for bent lamination and more time focused on producing the final piece. In this instance, the festool machine was not even needed!
jeff