There are many people on the forum who make edge lit acrylic “signs”. There is a new type of LED strip suitable for edge lighting. It uses WS2812 LEDs which are becoming available at reasonable prices. Although they are in a single string, each LED is Green/Red/Blue and each color has 256 levels of brightness. Further, each LED in the string is individually controlled. Here is a link to one of the suppliers:
http://www.bing.com/videos/search?q=ws2812+led+video&mid=B1282218BA22255098DE B1282218BA22255098DE&view=detail&FORM=VIRE2
The link below is a video of a WS2812 LED string.
http://www.bing.com/videos/search?q=WS2812+video&mid=79261D2D450CBCB7B5B67926 1D2D450CBCB7B5B6&view=detail&FORM=VIRE1

I have one of these LEDs running off a PIC microcontroller. I was very surprised how bright the LEDs are and when GRB are turned on max they produce a very convincing cold white.

The strings are available as “waterproof” which may open interesting outdoor applications.

Most (if not all) of the strips can be cut to the required length by cutting between any two LEDs. ( I would not recommend trying to make your own strips. The chips are extremely small.)

A controller is required to control the LEDs. I have seen some simple controllers for about $9 on ebay.

For the technically inclined:
1. The interconnect between the LEDs in the string is ground, +5, data in, and data out to the next LED.
2. The power requirements are rather forgiving.
3. The documentation states that the pulse stream is a NRZ protocol. It is not a NRZ coding. It is a rather simple pulse width encoding scheme; a narrow pulse is a zero and fat pulse is a one. If no pulses are detected for a nominal 50uSec the WS2812 LED assumes that the “talking is over” and latches the GRB bytes into the respective GRB constant current source. These values are retained until the next data stream or power is lost.
4. I have C18 C code that I wrote for a PIC 18F2525. It will control 32 LEDs and is updating the LEDs at 50Hz. I “bit bashed” the interface and would be happy to share the code. It requires a processor that runs at 8M inst/sec or faster. It may be possible to run at 4M inst/sec by tweaking some of the delays.
5. The data sheet for the WS2812 is rather poor; however, I have to admit that the overall design is rather clever and my sincere congratulations to the designer.
Paul Z