I think one probable reason why these configuration files get corrupted is from shutting down a computer by putting it to sleep, then while it's asleep, the power fails or the computer resets itself (Windows is like God and works in mysterious ways), which could corrupt files that are open. My suggestion would be to first, make sure your computer is on a UPS and second, on Friday, shut the computer down completely by going through the power down sequence instead of pressing the power button (that puts it to sleep).
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