I have my dust collector in the next room. It's one of the better decisions I've made. I upped the line to 6" to compensate.
Moving the duct collector did a number of positive things:
1. Lowered the noise. When cutting with a small end mill, I can skip the hearing protection. When working in the room with the dust collector (it's hooked to several machines), I have to use the mickey mouse ears.
2. Provide a negative pressure in the CNC room. This keeps the inevitable dust kicked up by the CNC isolated to the one room as air flows from the dust collector out of the room through the hose and back in through the doorway. I'm big on a clean shop and this helps.
3. Gets that big machine out of the CNC room. I had space for it and almost installed it next to my CNC but now, it's far easier to reach the dust collector to empty the bin and maneuver around the CNC than it would have been if I left them in the same room.
The only downside is the longer length of pipe but since I upped it from a 5" to a 6" line, that's not an issue.
I keep the hold down vacuum under the table. Too darn convenient to place it anywhere else. I don't use it that much anyway.
ShopBot Details:
2013 PRS 96x60x12 (Centroid upgrade)
4hp Spindle
12" indexer
Aspire
Rhino
Fusion 360
Ferrari 360
Prusa MK3S+
Prusa XL multi-tool