Try typing in a VI Command and look at your Comm Port Number. and make sure that enable steps and output is turned on.
You can also try pluging in the usb hub to a diffrent usb port on the computer. Iv'e had to do that in the past.
You can also go into your divice manager on the computer and look for your usb controllers to see if there may be a problem there.

Have you looked at your help manuel? If not it is located C/Program Files/ ShopBot/ShopBot3/Help. There is alot of usefull information there.